Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death
نویسندگان
چکیده
Background By exploiting the paramagnetic properties of deoxyhemoglobin, blood oxygen level-dependent (BOLD) MRI can detect myocardial ischemia in patients with coronary artery disease. However, little is known about myocardial tissue oxygenation in pathological left ventricular hypertrophy (e.g. HCM) or physiological hypertrophy (e. g. elite athletes). Perfusion studies have shown that patients with HCM show evidence of microvascular dysfunction, however, whether this leads to de-oxygenation and ischemia is unclear.
منابع مشابه
Apical Hypertrophic Cardiomyopathy in a Case with Chest Pain and Family History of Sudden Cardiac Death: A Case Report
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease, which is caused by a multitude of mutations in genes encoding proteins of the cardiac sarcomere (1). Apical hypertrophic cardiomyopathy (AHCM) is an uncommon type of HCM. The sudden cardiac death is less likely to occur in the patients inflicted with AHCM (2). Herein, we presented the case of a 29-year-old man ...
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